The investigators also found the antidepressant influence of NV-5138 is mediated by upregulation of brain-derived neurotrophic component (BDNF) signaling Which NV-5138 procedure generates fast synaptic responses in the medial prefrontal cortex. These results emphasize the immediate activation of mTORC1 signaling as a possible pharmacological intervention to the treatment of melancholy. https://englandl666ykv9.cosmicwiki.com/user