This mechanism might be through the induction of hepatic microsomal enzymes that metabolize the antibiotic. If phenobarbital and doxycycline are administered concurrently, the scientific response to doxycycline ought to be monitored closely. Phenytoin, sodium valproate, valproic acid: The result of barbiturates over the metabolism of phenytoin appears to become variable. https://jamesz589acc3.wikiconversation.com/user